The model includes a basic pharmacodynamic response (to assembled virions) to cause cell apoptosis. This heavy usage might lead to bottlenecks when it comes to setting up new meetings, or to disruptions when starting meetings. Am Samstag, 9. A research team from the Chair of Economic Geography at the University of Jena has been examining the severity of the consequences. Our team is mostly working online. Due to the corona virus, Graduate Academy has to reduce some of its offers. There may be longer waiting times. PoSeiDon is a pipeline to detect significant positively selected sites and possible recombination events in an alignment of multiple coding sequences. �:M�l��Μق��D�;];��#�%2�T�t��z$ ��M�l�H�h���F]��*Vwb�C�GܲCE�V�q���e�!����� SD}��ٌ[:/�*F�Л��q�֙Xp�;��p�l�2�����Q/>~j؃�ܒcGIDP�?��u���B.S Lectures during Corona. Both ELM and IUPred2A identify functional regions that are disordered and generally less conserved due to rapid evolvability, and hence their outputs complement the well conserved functional regions identified by Pfam. Letzter Stand: 16. The IUPred2A server is a biophysics-based prediction to identify intrinsically disordered protein regions (IDRs) and binding sites inside IDRs. Users may also analyse their own SARS-CoV-2 sequences by submitting them to the web application to receive an interactive report containing visualisations of phylogenetic classification and highlighting genomic variation of potentially high impact, for example, linked to primer mismatches. This also applies to the exams. Please also use the e-mail address corona@jena.de. Step-by-step guide. Bulgaria’s Corona-Drama in Three Acts. Sites that undergo positive selection can give you insights in the evolutionary history of your sequences, for example showing you important mutation hot spots, accumulated as results of virus-host arms races during evolution. For the third year Bachelor Biology course “Vom Molekül zu komplexen Gemeinschaften (BB3.Ö13)“ at FSU Jena, PhD student Jennifer Gabriel and research group leader Nicole van Dam, Molecular Interaction Ecology designed a Corona proof “brown bag” practicum. CoVex is a unique online network and systems medicine platform for data analysis that integrates virus-human interactions for SARS-CoV-2 and SARS-CoV-1. The Pfam profile hidden Markov model (HMM) library in combination with the HMMER software facilitates rapid search and annotation of coronaviruses and can be used to generate multiple sequence alignments that allow the identification of mutations and clusters of related sequences, particularly useful for outbreak tracking and studying the evolution of Coronaviruses. We are happy to answer your enquiries via our contact form. ,)�t*�;ʖVq����w���p6ʯQ73�c��8k9O>X3̪? DisGeNET COVID-19 data collection shows the results of applying text mining tools to the LitCovid dataset, to identify mentions of diseases, signs and symptoms. The annotation system is based on the analysis of the input nucleotide sequence using models built from curated RefSeqs. Informieren Sie bitte auch das Internationale Büro der Universität Jena: international@uni-jena.de H���C�bTB���I1�\�Œ��g��v�H��[6v3y�-���� �2m�B��kħ��3�0ϸ��q�q�ʘ�n�Oڸ������-2ѸMΰ'Аr�|9�J���딶�k7��S���z�T�:ǔ���.e�B�+�j��9� ��]����׻�7UZBݮ�3�����X5����� ����,���ϻ��9uļ�����]o�؂�#>5)p��6�������y���r����l�C��n���������?�����l?t7t���]��$k�}W8x��sS���6Ѻߦ���m¡ߖX5n�>]l�@�)�˟6J��'". ViralZone project is handled by the virus program of SwissProt group. Despite the fact that first facilities are re-opening under strict conditionshis, we ask you to learn and to work from home whenever possible and, in your personal behaviour, take into account that great efforts are still needed to contain the corona virus. "doc-in" is the online administration for doctoral procedures at the Friedrich Schiller University Jena and accompanies you through the entire PhD phase. The virus is uncoated to explose viral RNA, which synthesizes viral proteins that are assembled into a virion. Please also have a look at our general list of virus bioinformatics tools. The ELM resource offers a collection of short linear motifs that mediate interactions crucial in both native cell regulation and pathogenic interference. ������4�v K�W\-�z0�d�]��� ��ӌ{u�Ē�J��a �b�;%�F*���­��Ql��(�E������6ٹ����%�0:�w���ѐK!��Ժ�xi atm�5A�=5�YƝ�=M���};�J��qgMĤ\�����+������8�����.�,~|�0�;����*uh���v}�i �R��ƛ��m�ʽ���&�KD��6�,�+�3/n�P��%Bi�d�۾Go��Z�������q6���N�ŧx����Uc8��ۯ���Hf�h��_���F/Rs:Ѹ��_·��p_�6B:�g"a It tackles the computationally expensive steps with linear runtime filters and efficient encodings. CoVPipe is a highly optimized and fully automated workflow for the reference-based reconstruction of SARS-CoV-2 genomes based on next generation amplicon sequencing data using CleanPlex SARS-CoV-2 Panel (Paragon Genomics, Hayward, CA, USA) from swab samples. Rufen Sie in jedem Fall Ihren Hausarzt in Deutschland (alternativ die Hotline 116117) an. The latest release of Pfam, version 33.1, contains an updated set of models that comprehensively cover the proteins encoded by SARS-CoV-2. Service hours of the hotline: daily 10:00 - 14:00. uni-assist has already taken comprehensive protective measures for the staff in its Berlin office. This is a fast-paced project with the COVID-19 Data Portal featuring relevant … However, we are still available for you via email. Encountering Covid-19: Jamais vu or Déjà vu? The corona pandemic is fundamentally changing the everyday life of many people – this naturally also affects students. International organizations take action in order to prevent a further spread of the virus—with the World Health Organization (WHO) leading the … Our team is mostly working online. You can search the comprehensive database for sequences & strains, immune epitopes, 3D protein structures, host factor data, antiviral drugs, plasmid data. The Data Portal brings together and continuously updates the relevant COVID-19 datasets and tools. Visit the SARS-CoV-2 data portal in ViPR. PriSeT finds a primer set P balancing both: high taxonomic coverage and high resolution. It allows for the detection of within-host genetic variation of SARS-CoV-2 from viral NGS data. For example, it is possible to search for a fragment of a SARS-CoV-2 genome, select similar sequences identified in COVID-19 patients, and browse sequence variants from different countries. This can capture longer and more specialized disordered interaction regions complementing linear motifs captured by ELM. This literature curation effort is now, Complete the online application form providing answers as directed Ensure you add relevant information to the “Application submission” section where you are asked to provide three 100-word paragraphs that cover your: scientific biography work history current research interests Upload a letter of support from your supervisor or a senior colleague, Complete the online application form Ensure you add relevant information to the “application submission” section where you are asked to provide three 100-word paragraphs that cover your: scientific biography work history current research interests Upload a letter of support from your supervisor or a senior colleague detailing reasons why you should be selected, International Virus Bioinformatics Meeting 2020, SARS-CoV-2 genome browser and related resources, Phylogeographic reconstruction using air transportation data. Find putative drug targets. With sadness, we regret to inform you that we have to cancel our 7 th pairfam international interdisciplinary conference on "Personality and relationships across the life span in Jena", July 2-3 2020, due to the evolving corona virus situation. Apoptosed cells release some or all of their internal contents, notably including virions. Mai, findet der Hochschulinformationstag (HIT) der Universität Jena erstmals digital statt. We will meet the challenges head-on. The University of Jena, officially the Friedrich Schiller University Jena (German: Friedrich-Schiller-Universität Jena, abbreviated FSU, shortened form Uni Jena) is a public research university located in Jena, Thuringia, Germany.. It implements different network-based approaches for the identification of new drug targets and new repurposable drugs. ��%����SIG�{ ��jx���A���l���-���8%�ES�kk`�,�-�$�B�Tm{����L̃��xS�SEV��*e�.�Jlۄ����ֶ�"R\��V�2����1�Z�L��V�I��d��Z�Lʲ]Ȕض�i�9����) The viral sequences are regularly extracted from the NCBI BLAST database and the metadata is retrieved from the associated INSDC entries. For a detailed description of the tools, check our review preprint: We are curious to know which tools you have developed to advance the field. The COVID-19 portal enables community crowdsourcing of publications via the “Add a publication” feature within any entry. It can be used as a method of reconstructing phylogenies but is also a framework for testing evolutionary hypotheses without conditioning on a single tree topology. COPASI supports models in the SBML standard and can simulate their behavior using ODEs or Gillespie’s stochastic simulation algorithm; arbitrary discrete events can be included in such simulations. Medizin-Studierende oder Personen mit medizinischer Vorbildung, die sich engagieren möchten, können sich an Karsten Krohn vom Universitätsklinikum Jena Krohn@med.uni-jena.de wenden. Its main focus is set on drug interactions either addressing viral proteins or human proteins that could be used to treat COVID. Nextstrain is an open-source project to harness the scientific and public health potential of pathogen genome data. Pufferlösungen für PCR-Tests The latest release (March 2020) is dedicated to helping researchers to fight against the COVID-19 pandemic and is registered as a COVID-19 fair share resource. CORDITE (CORona Drug InTEractions database) collects and aggregates data from PubMed, MedRxiv, BioRxiv, and ChemRxiv for SARS-CoV-2. 5Institute for Medical Microbiology, University Hospital Jena, Am Klinikum 1, 07747 Jena. The GISAID Initiative promotes the rapid sharing of data from the coronavirus causing COVID-19. They provide a continually-updated view of publicly available data alongside powerful analytic and visualization tools for use by the community. Oral examinations in the context of doctoral and habilitation procedures (disputations, colloquia, scientific lectures and talks) are currently not to be held. The Data Portal brings together and continuously updates the relevant COVID-19 datasets and tools. Restrictions due to Corona virus: Regulations for PhD and habilitation procedures. Indeed, this tree has never borne so much fruit, and so superb. 6Qᠨ�Y(%�B7�R �ܣ:2�&�L0�fcOR�����L���Z�/X��m�i�s��+�7��4�x��T�~� ���z^���� SARS-CoV-2 will naturally accumulate nucleotide mutations in its RNA genome as the pandemic progresses. ���n1�P�G�,�t\5t����W Qe�.f�R��L�)��#��!sߐQbs�k�+�f���Hj�"z�c��?��NT���I�O ִ� E-Mail: Please write an email to LehreLernen@uni-jena.de. Corona Hotline 0049 3641 49-2222. First Act. On 20 March, the Friedrich Schiller University Jena went into emergency operation. The nationwide survey "Studying in Germany in Corona Times" aims to examine the effects of the crisis on students at German universities and to shed light on the special features, challenges and opportunities of the largely digital summer semester 2020. Barrierefreiheit. Sequence data are essential to design and evaluate diagnostic tests, to track and trace the ongoing outbreak, and to identify potential intervention options. The tool allows users to highlight and prioritize the most frequent mutations in specific protein regions, and to monitor their frequency in the population over time. DisGeNET is a discovery platform containing one of the largest publicly available collections of genes and variants associated with human diseases. The release contains manual biocuration of experimentally validated physical Coronaviridae / host protein-protein interactions and is complementary to functional and in silico interactions shared by viruses.string. This includes genetic sequence and related clinical and epidemiological data to help researchers understand how viruses evolve and spread during epidemics and pandemics. Beautiful, sweet-smelling, delicious apples. Corona-News: Thüringer mit medizinischer Erfahrung gesucht - Jena meldet Rekordwert 36 Menschen, die mit dem Coronavirus infiziert waren, sind innerhalb eines Tages in Thüringen verstorben. information on gene functions from Gene Ontology, Support for facets and keyword searches for exploring results, Explore up to 1,000 top hits (compared to 100 in BLAST), Integration with Rfam to annotate structured RNA elements. Designed using Hoot Business. Jena, July 2-3, 2020. Vigor4 uses the VIGOR_DB project which currently has databases for the following viruses: Influenza (A & B for human, avian, and swine, and C for human), West Nile Virus, Zika Virus, Chikungunya Virus, Eastern Equine Encephalitis Virus, Respiratory Syncytial Virus, Rotavirus, Enterovirus, Lassa Mammarenavirus. Tools by EVBC members are marked ★. VirHostNet is a knowledge base for the management and the analysis of proteome-wide virus-host interaction networks. RNAcentral has launched a new tool to help scientists studying Coronaviruses to search thousands of viral genomes and explore results by virus, host, country, and more. The pipeline is designed for reproducibility and scalability in order to ensure reliable and fast data analysis of SARS-CoV2 data. COVID-19 UniProt portal provides early pre-release access to (i) SARS-CoV-2 annotated protein sequences, (ii) closest SARS proteins from SARS 2003, (iii) human proteins relevant to the biology of viral infection, like receptors and enzymes, (iv) ProtVista visualisation of sequence features for each protein, (v) links to sequence analysis tools, (vi) access to collated community-contributed publications relevant to COVID-19, as well as (vii) links to relevant resources. the routine detection of SARS-CoV-2 infection. 4Institute for Pharmaceutical Technology and Biopharmacy, Friedrich Schiller University Jena, Lessingstrasse 8, 07743 Jena. The ELM server includes an online tool for the identification of motifs in user input sequences, using context filters (based on structural information, localization, sequence complexity and conservation) to refine results. In the extracellular space, virions adhere to ACE2 receptors and get internalized through endocytosis. The political actors therefore don’t stop at their borders on the search for solutions. uni-assist has already taken comprehensive protective measures for the staff in its Berlin office. Each virus or family page gives an easy access to UniProtKB/Swiss-Prot viral protein entries. Assembled virions are exported to the environment, where they can diffuse and infect other cells. Please register as a doctoral candidate in the doctoral candidate portal "doc-in". /� ��lJ�4��s����2�����7���a)h��D�u��s�f�N?�}=��B��t2c}��'@ҟ�@Ճ_/�������h��d��ejΘ��+��!T��;�)a�������7S��̉*-����p��/!�`����к/�fȋ�����/` �+������0��4�.^Ã��`#�k��r4ܣ��ǐ�U/pC��={���� {C��hQ9OL�ˮx>�~�*�+���O!��Q}$��~�����1T)�5Q���/.�0��[���zi��\'��y ��X��C���]w�z.v�޻.x��4،�ӓ~Ķ���!a���A�7��{�I�V�4����7�|j-�j%>��_����9*{odj��ğ�r�Y�M�-�1(d���:���U/���a(���׈u��Үp���%f�w����GO��t�Tثd���àR{�L7�|Ap�j,�d)i ËtV��c2�q�I���q]��d�9�G$y%���Z��A�É�f�p�S�q�'�}��alה�1��C�=���@q/&c��T8�ɑ�G�M/�C�/ͩ��I&��՝������hb�E�R�ތ�!T@��D*�r��\�:��'&�E /�٧�o�K��$ƒ�G�ͣ�M�q�����KO'\3��_����5g�,�dT�[j��y����< �*�y+9�%���Қs�e���s0���0�&(��/����3�M��8�(��:U:OLp�u�lad�q���0g6�M}��˭�q�����v�=|� �/��77�$ The Master's programme starts in the winter semester 2020. Thuringia’s economy has been hit hard by the corona pandemic, plunging the state into a deep recession. International Organizations and Crisis Management - IOCM in short - is the masters degree in political science of the Chair for International Relations at the Friedrich-Schiller-University Jena. BEAST 2 includes a graphical user-interface for setting up standard analyses and a suit of programs for analysing the results. Handlungsempfehlungen an Lehrende und Prüfungsämter kommuniziert, auf die sich Studierende berufen können. ORCID is used as a mechanism to validate user credentials as well as recognition for contribution. This tool is a work in progress and any suggestions would be greatly appreciated. This applies initially until the start of the summer semester lecture period on 4 … P-HIPSTer employs structural information to predict pan viral-human PPIs. Corona virus: Availability and Restrictions at Graduate Academy. On average the observed changes would be expected to have no or minimal consequence on virus biology. Further you can analyze the data online using sequence alignment, phylogenetic tree reconstruction, sequence variation (SNP), metadata-driven comparative analysis and BLAST. The European COVID-19 Data Portal was launched by EMBL-EBI in conjunction with the European Commission, the European Open Science Cloud and ELIXIR, as part of the wider European COVID-19 Data Platform. Please note: Due to the Corona crisis DFN-web conferencing tools are currently frequently used. It is capable of processing large libraries and is robust against mislabeled or low quality references. Welcome to the Chair of International Relations at Friedrich Schiller University Jena! Präsidium und Senat der Friedrich-Schiller-Universität Jena haben sich zum Ziel gesetzt, alle Nachteile, die Studierenden durch Corona entstehen, auszugleichen. COPASI is a software application for simulation and analysis of biochemical networks and their dynamics. PriSeT has been applied to 19 SARS-CoV-2 genomes and computed 114 new primer pairs with the additional constraint that the sequences have no co-occurrences in other taxa. Among them is the ACP auditorium, where main lectures in the M.Sc. ViralZone is a web-resource from the Swiss Institute of Bioinformatics for all viral genus and families, providing general molecular and epidemiological information, along with virion and genome figures. the tracking of the COVID-19 pandemic and evaluation of containment measures. The opening page has been updated to give references to an overview of motif hijacking in viruses in general, and an application to detecting SARS-CoV-2 motif usage in host cell attachment and modulation. The European COVID-19 Data Portal was launched by EMBL-EBI in conjunction with the European Commission, the European Open Science Cloud and ELIXIR, as part of the wider European COVID-19 Data Platform. It will determine Currently, it supports FMDV and SARS-Cov-2 viral sequences. BEAST 2 uses Markov chain Monte Carlo (MCMC) to average over tree space, so that each tree is weighted proportional to its posterior probability. coronapp is a web application to annotate and monitor SARS-CoV-2 mutations, both worldwide and in user-selected countries. Through a review of the most relevant scientific literature, and considering different levels of experimental evidence, over 150 compounds have been identified that are potentially active against COVID-19. The Welcome and Service Desk for Doctoral Candidates and Postdocs will be closed for face-to-face contacts until further notice. Essential information concerning this matter is … Photonics course are held, e.g. If you wish to start a PhD at the University of Jena you have to register in the portal with your personal data. All tools are freely available online, either through web applications or public code repositories. UniProt also hosted webinars to describe the portal and publication submission system. This way users can get a fully annotated report on candidate disordered interaction sites, highlighting their relationships with Pfam domains, for any protein of interest. VADR (Viral Annotation DefineR) validates and annotates viral sequences in GenBank submissions. With great discipline we have all contributed to keep the number of sick people in Jena low. Coronavirus COVID-19 Global Cases by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU) the reliable analysis of sequencing data. Appropriate PCR primer pairs for DNA metabarcoding would match to a broad evolutionary range of taxa, such that we only need a few to achieve high taxonomic coverage. And our most important services will continue: We are processing all incoming applications including your mail. We are curating a list of bioinformatics tools designed explicitly for SARS-CoV-2 and coronaviruses. r�F�32� 9W The Lecture Hall Management section will support you in complying with the protection regulations. The COVID-19 UniProt portal advances SARS-CoV-2 research by providing the latest knowledge on proteins relevant to the disease for both the virus and human host. The Friedrich Schiller University Jena has equipped several lecture halls to provide live streaming of lectures and seminars.

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